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Indicator #1 Unprecedented Growth: GLP-1 Products Redefine Revenue Trajectories (FIGURE 1) Since launch, GLP-1 drugs have generated a cumulative $71 billion in US revenue and they are projected to amass $400 billion more in the coming years to reach $470 billion by 2030

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von Scholten BJ, et al

Genetic variations in GIP and GLP-1 receptor sensitivity, differences in gut microbiome composition, metabolic adaptation, and individual hormonal profiles all influence how much weight a person loses

Despite the different doses of semaglutide and tirzepatide and timepoints studied, the results of SURMOUNT-5 and the Truveta Research study were consistent, namely that tirzepatide-based medications performed better than semaglutide-based medications: SURMOUNT-5 study : At 72 weeks, weight loss was 20.2% for Zepbound (tirzepatide AOM) compared to 13.7% for Wegovy (semaglutide AOM)

The difference shows up in where on the titration schedule each person finds their effective maintenance dose