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Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders

As MBS leaderand Accomplish Health advisorJOHN MORTON puts it: Combining surgical approaches and GLP-1 receptor agonist therapy presents an opportunity to further improve outcomes for patients undergoing MBS. --- Review: Combining Medications With Bariatric Surgery to Treat Obesity To view or add a comment, sign in Compared with GLP-1 RAs, bariatric metabolic surgery was associated with lower rates of: All-cause mortality Major adverse cardiovascular events (MACE) Nephropathy Retinopathy These findings indicate that even with the availability of GLP-1 RAs, metabolic surgery remains superior to medical treatment for macrovascular and microvascular outcomes in patients with diabetes and obesity

Introduction With the advancement of the social economy and alterations in lifestyle patterns, chronic metabolic disorders like obesity and diabetes have emerged as major public health issues (1, 2)

It boosts hepatic LDL-C receptor expression by inhibiting the activity of PCSK9 (proprotein convertase subtilisin/kexin type 9) [47], and reduces triglycerides via AMPK activation and inhibition of the MAPK/ERK pathway (Fig