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The totality of these changes puts tirzepatide in a different category from previous weight loss medications and positions it alongside bariatric surgery for overall efficacy, a comparison that would have seemed absurd just a few years ago

doi: 10.1007/s13679-021-00453-x 262 BalJIlonzoNAdedijiTLeitmanIM

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Here we investigated the clinical response of men and women in the SURMOUNT-1 trial who carried pathogenic mutations in the melanocortin 4 receptor ( MC4R ) gene, the most common genetic cause of obesity
These symptoms are usually localised and often improve within a few days
