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However, the use of reliable and robust mathematical models with predictive capabilities, known as the quantitative pharmacology approach (QP-A) and model-based drug development (MBDD), holds promise as a supportive strategy

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While some patients report it, it is less typical than recognised effects such as nausea, vomiting or abdominal discomfort

57 Other novel biomarkers include noncoding RNAs, 58 miRNAs, 59,60 and lncRNAs 61 (e.g., miR-21, miR-146a, miR-155, lncRNA HOTAIR, and lncRNA NEAT1)

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