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For decades, obesity pharmacology was constrained by single-pathway thinking: block appetite here, improve insulin there

Moreover, 1.84 million people have visually threatening DR, about 5% of patients with diabetes

However, topiramate is currently used in combination with phentermine as an FDA-approved therapy for weight loss

3,4 This specific configuration is believed to generate a synergistic effect that exceeds the efficacy of merely combining two separate agents

J Am Coll Cardiol (2006) 47(8 Suppl):C712

At the same time, oral GLP-1 therapies such as Eli Lillys orforglipron may significantly broaden treatment access