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Description
As of 2022, GLP-1RAs have been recommended as first-line treatments, along with SGLT-2 inhibitors, for patients with T2DM and cardiovascular disease in American Diabetes Associations Standards of Medical Care in Diabetes (248, 249)
Use for acute episodes only

Song X, Jia H, Jiang Y, Wang L, Zhang Y, Mu Y, et al

Typical GLP tolerance and side effect profile These efficacy results approach those seen with weekly injectable formulations , even though oral delivery historically posed challenges due to absorption limitations in the gut

However, the UACR reduction was not significantly different ( The REWIND study evaluated the cardiovascular safety of dulaglutide (1.5 mg) in comparison to placebo ( Exenatide The EXSCEL (Exenatide Study of Cardiovascular Event Lowering) trial evaluated the CV safety of exenatide (2 mg weekly)

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