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for example, weight loss associated with the use of GLP-1 RAs in people without cancer may be associated with the prevention of obesity-related cancers

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the endocytic adaptor Epsin binds to the ubiquitinated intracellular domain, and the resulting Clathrin-mediated endocytosis exerts a pulling force that exposes the cleavage site in the NRR [[4][4][6][5]]