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6.1 Antioxidant effects GLP-1 receptor agonists exhibit potent antioxidant effects in sepsis by enhancing the expression and activity of key enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase, which effectively neutralize ROS that are major mediators of cellular injury during sepsis

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Studies typically begin with a low titration phase to allow receptor adaptation (e.g., 2mg or 4mg weekly), increasing slowly over months to reach the target maintenance dose (up to 12mg in some trials, though this product contains 20mg total)

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Day 61 or thereafter if : If no additional glycemic control is needed, then maintain the dosage at 4 mg orally once daily