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These trials back the advice for its long-term use

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Here are some signs that your B12 might be running low: Feeling unusually tired or weak even after resting Tingling or numbness in your hands or feet Difficulty concentrating or brain fog Dizziness or lightheadedness A sore or swollen tongue Pale or slightly yellow skin Mood changes like irritability or low mood These symptoms can overlap with other things going on when you are losing weight quickly, so they are easy to overlook

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NICE TA875 specifies that NHS access to semaglutide for weight management is restricted to specialist weight management services (tier 3 or 4) for patients meeting specific criteria