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This extended pharmacokinetic window means that once-weekly dosing maintains steady GLP-1 pathway activation throughout the week

Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5)

In addition, one study suggested that activating presynaptic GLP-1Rs may alter glutamate signaling in the VTA and, in turn, modulate midbrain dopamine cell activity 45

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[Lys40(Ahx-DTPA-111In)NH2]-exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptortargeted therapy for insulinoma