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Description

Peptide denaturation from freezing is a structural change at the molecular level that cannot be undone by any thawing method

Signs of a hypersensitivity reaction include: Hives Loss of consciousness Nausea and vomiting Rash Shortness of breath Stomach cramps Wheezing Tirzepatide drug labels warn against hypersensitivity reactions, including anaphylaxis and angioedema

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Future directions Considering the GLP-1 RAs currently available for treating T2DM and obesity, along with the numerous new GLP-1 RAs, dual, and triple agonists in development, we anticipate a shift in clinical practice towards more personalized and tailored use of these agents to meet individual patient needs

We recently encountered a similar case at our institution - a 49-year-old woman with type 2 diabetes, obesity, and chronic pain on long-term narcotic therapy, who presented with abdominal distension and vomiting after two years of tirzepatide (Mounjaro) therapy