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[8] [9] Safety Considerations When Combining These Medications Although combining Januvia and Rybelsus is not generally recommended in UK practice, understanding the safety profile of each medication is important

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They mimic the natural GLP-1 hormone, helping people feel fuller, eat less and improve post-meal glucose control (Collins 2024

Patients should seek immediate medical attention for severe persistent abdominal pain (possible pancreatitis), right upper quadrant pain with fever (possible gallbladder disease), severe vomiting leading to dehydration, decreased urine output (possible acute kidney injury), or significant vision changes (possible diabetic retinopathy complications)