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The albumin-bound peptide is also hypothesized to interact with the neonatal Fc receptor (FcRn), allowing it to shuttle through the albumin recycling pathway and evade intracellular degradation, thus, significantly increasing the circulation half-life [61]
10.1136/bmj-2023-076410
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Involvement of glucagon-like peptide-1 in the regulation of selective excretion of sodium or chloride ions by the kidneys
PI3K: phosphoinositide 3-kinase
Accordingly, mediation analysis of LEADER and SUSTAIN-6 suggested that HbA1c and SBP lowering might partially mediate the GLP-1RA renal benefits
