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In this case, although GLP-1 users had about twice the relative risk of ischemic optic neuropathy compared to other drugs, the absolute increase was only around 3 to 4 extra cases per 10,000 people over 18 monthsmeaning the overall chance remains very small

doi:10.1152/ajpendo.00069.2016 Gupta NA, Mells J, Dunham RM, et al

In 1970 the glucagon precursor, proglucagon, was identified

Still, psychiatrists like Georgios Schoretsanitis at the University of Zurich and Chiara Gastaldon at the University of Verona saw a need for additional analyses while the regulatory agencies were reviewing their own datasets

Similarly, the LEADER trial with liraglutide showed a numerically higher, though non-significant, rate of diabetic retinopathy events compared to placebo (HR, 1.15