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High-intensity exercise temporarily raises cortisol, which is fine occasionally but counterproductive during high-stress periods

This is not because patients dislike autoinjectors - evidence shows they generally don't mind and some prefer weekly dosing

Approved oral formulations can work for some patients, but they require strict administration and are generally less bioavailable

[15] [16] Budesonide MMX may be considered for some patients with mild-to-moderate UC

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