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After 56 weeks: Placebo group lost 1.6% of body weight Starting dose (3.75/23 mg) group lost 5.1% of body weight Top dose (15/92 mg) group lost 10.9% of body weight Beyond weight loss, the CONQUER trial showed significant improvements in blood pressure, waist circumference, lipid profiles, glycemic parameters, and inflammatory biomarkers compared to placebo

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An examination of the differentiation of CD4 T cells under diverse conditions, such as those promoting the development of Th1, Th2, Th17 cells, and Tregs, demonstrated that the GLP-1R was most prominently expressed on induced regulatory T cells ( i Tregs) [13]