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Not all patients will be willing or able to take these GLP-1 drugs for many years, though, and its important that studies are done to better understand how to help individuals who want to wean off them

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Amgen appears to have a competitive edge Amgen is testing out a once-a-month or even less frequent basis for its drug, which would be more convenient than the weekly medicines on the market

Nat Rev Gastroenterol Hepatol 2019;16:377-386

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in patients with type 2 diabetes mellitus, the incretin effect is responsible for less than 20% of the insulin response to an oral glucose load, whereas it accounts for roughly two-thirds of the response