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Introduction Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), remain a major cause of disability worldwide, with lifetime prevalence exceeding 15% for depression and up to 3% for bipolar disorder, with more than 400 million people affected by depression [1]

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This same pathway is being investigated as a potential treatment for migraine and a condition called idiopathic intracranial hypertension, where preliminary studies have shown promising results in reducing headache frequency

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