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If you don't eat enough of these, or if your body doesnt absorb them well, you may develop nutritional deficiencies

Yousseif A, Emmanuel J, Karra E, Millet Q, Elkalaawy M, Jenkinson AD, Hashemi M, Adamo M, Finer N, Fiennes AG, Withers DJ, Batterham RL

The STEP 1 trial of semaglutide (the active ingredient in Ozempic and Wegovy) - published in The New England Journal of Medicine , 2021 - also reported secondary data showing modest lean mass reductions alongside the significant total weight loss the trial is known for

This slower digestion process requires energy expenditure and can leave you feeling drained, particularly during the first 24 weeks of therapy

Amisten, S., Salehi, A., Rorsman, P., Jones, P

OFA also submitted a comment to the FDA that argues the semaglutide shortage remains ongoing: OFA conservatively estimates that roughly 80 million prescriptions for semaglutide were fulfilled with compounded semaglutide in the last 12 months, inclusive of 503A pharmacy compounders and 503B outsourcing facilities