5th gen glp 1 agonist From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics Nutritional priorities to support GLP-1

2024;48(1 Suppl 1):s181-s206

doi: 10.1074/jbc.M508542200

1).29,32 With respect to the vascular system, rGLP-1 activation induces modest decreases in blood pressure,33,34 it has a vasodilator effect, improves arterial stiffness, and prevents atherosclerotic plaque formation-and has plaque stabilizing effects-through its anti-inflammatory and antiapoptotic effects as demonstrated in animal models.29,32,3538 Despite controversies about rGLP-1 expression in vascular smooth muscle and endothelial cells, studies have shown that arGLP-1 has antiproliferative effects on these cells,39 reduces oxidative stress, improves endothelial function, and increases nitric oxide production in experimental models.3540 In the heart they produce a discrete increase in heart rate (24 beats/min), although this does not seem to be associated with an increase in arrhythmias or cardiovascular events

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Liraglutide and semaglutide were the most frequently investigated GLP-1RAs

Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, et al