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McGuire, found that oral semaglutide reduced major adverse cardiovascular events (MACE) to 3.1 events per 100 person-years, compared to 3.7 events in the placebo group a 14% reduction (HR 0.86) over a median follow-up of 49.5 months

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The problem, however, was that the molecules half-life was much too short to serve as a useful medicine

Those taking tirzepatide, achieved an additional 18.4% WL from randomisation to 72 weeks compared to those taking placebo who experienced weight regain of 2.5% [48]

However, some doctors may prescribe it off - label for women with PCOS, particularly when insulin resistance or weight gain are major concerns