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6 Oral administration of P9 reduces adipose tissue mass and induces thermogenesis in high-fat diet-fed mice

Also called delayed gastric emptying, gastroparesis is when the nerves and stomach muscles become weak and unable to move food properly through the body

Feeding a high-fat diet to C57BL/6J mice for 816 weeks is the most commonly used method for establishing the HFD model

2014, Yusta et al

For a detailed comparison of oral GLP-1 tablet formulations and injectable options, refer to the comprehensive review

These medications, originally approved by the FDA for the treatment of Type 2 diabetes, have since been authorized for weight loss therapy and are now recommended by the American Diabetes Association as potential first-line options for both indications