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Have tried lifestyle changes (like exercise, nutrition, and sleep) but havent seen meaningful or sustainable weight loss

Taking a smaller dose than what your doctor recommends isnt a good idea Image content: This image is available to view online

Topiramate, meanwhile, works more on the neurological side, dampening the reward sensation that makes certain foods so tempting

B.HaydenM
Being in an energy deficit tends to slightly decrease BMR

Saraceno N