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[DOI] [PubMed] [Google Scholar] 5.Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W

In a subgroup of participants with indicators of prediabetes, some of the two-drug combination therapy groups had 100% reversion to normoglycemia among participants with prediabetes at baseline, essentially moving them to a nonprediabetes status

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This inhibitory effect is attributed to the activation of the adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway and the concurrent downregulation of forkhead Box A1 (FOXA1) and sonic hedgehog (SHH) expression (Xie et al., 2020)