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Non-human primates, in particular Cynomolgus macaques (long-tailed macaques), were critical in determining how long-acting GLP-1 receptor agonist drugs are metabolised and cleared by the body, helping define proper dosing and delivery methods

Moran et al

doi: 10.1016/j.cell.2012.09.010

Not having the requisite laboratory skills to chemically determine these peptides, Drucker was encouraged by Habener to reach out to Mojsov for assistance in this work (Couzin-Frankel 8 Sept 2023)

Recent years have also seen a surge in demand for combination therapies and next-generation multi-agonists, reflecting evolving treatment paradigms and patient preferences

OFA also submitted a comment to the FDA that argues the semaglutide shortage remains ongoing: OFA conservatively estimates that roughly 80 million prescriptions for semaglutide were fulfilled with compounded semaglutide in the last 12 months, inclusive of 503A pharmacy compounders and 503B outsourcing facilities