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As described in the results section, the animals included in the experimental design, including the non-androgenized controls, were fed a high-fat diet with 58% kcal from fat, 25.5% from carbohydrates, and 16.4% from proteins (Research Diets, D12331)
More recently developed agents, in particular semaglutide, are characterized by greater efficacy with respect to lowering plasma glucose as well as body weight
In practical terms, this means that patients on GLP-1 prescription medications, such as Ozempic or Wegovy, feel less hungry, eat less, and lose weight
The difference is cost and accessibility, not therapeutic effectiveness
These active comparators included SGLT2i empagliflozin (PIONEER 2), inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitor) sitagliptin (PIONEER 7) and GLP1-RA liraglutide (PIONEER 4)
