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In man, the peptides glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are the major incretin hormones
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In the beginning of the twentieth century, a chemical study of active molecules contained in Galga officinalis demonstrated anti-hyperglycemic properties in diabetic patients ( Cellular targets of metformin The exact molecular mechanism of metformin's action remains unclear

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The Lancet Gastroenterology & Hepatology, 2024
