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Description
Separate solutions of fragment 1 and 2 in dimethylsulfoxide (DMSO)/acetonitrile (ACN), [Ethyl cyano(hydroxyimino)acetato- O 2 ]tri-1-pyrrolidinylphosphonium hexafluorophosphate (PyOxim) in ACN, and N , N -diisopropylethylamine (DIPEA) were made previously and brought together in flow prior to entering the PFR

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