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Despite the progress, the publications by Holst's team indicate that they did not yet know the entire amino acid sequence of the porcine peptide
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GLP-1 receptor agonists are incretin-based medications used for type 2 diabetes and obesity management
Phase III results for retatrutide are set to be released later in 2025 and in early 2026, but an earlier phase II trial recorded between a 7.2% and 17.5% reduction in body weight after 24 weeks, depending on the dose (7.2% on 1mg, 17.5% on 12mg), and up to a 24.2% reduction in body weight after 48 weeks for those on 12mg (-8.7% change for those on 1mg) 8
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Zhang, X., Belousoff, M.J., Liang, Y.L., Danev, R., Sexton, P.M., Wootten, D
