semaglutide update (Ozempic/Wegovy) shows 3-year efficacy for blood sugar control and weight loss 8 week update : r/Semaglutide

doi:10.1056/NEJMoa2403347 Data on file

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Extended exenatide administration enhances lipid metabolism and exacerbates pancreatic injury in mice on a high fat, high carbohydrate diet

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

Oral semaglutide 14 mg was associated with improved blood glucose levels and body weight versus liraglutide 1.8 mg after 52 weeks in the PIONEER 4 clinical trial

Whereas DIO control mice showed most consistent changes in KEGG modules associated with reduced bacterial sulfur metabolism, liraglutide and GUB09-145 effects on the gut microbiome were largely associated to effects on bacterial lipid metabolism (increased by liraglutide), sulfur metabolism (increased by both compounds), and Two-component regulatory system (modulated by both compounds)