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The appetite-inhibiting effect of GLP-1RA may depend on the 43% smaller decrease in free leptin levels, predominantly mediated by a 59% smaller increase in soluble leptin receptor, and higher PYY 336 meal responses may also contribute

Nature 477 , 549555 (2011)

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The GTP-bound -subunit dissociates from the trimer and activates adenylyl cyclase, which in turn produces large amounts of cyclic AMP (cAMP) from ATP within the cell