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Patients with pre-existing gallbladder sludge or small asymptomatic gallstones detected on imaging may be at higher risk for progression to symptomatic disease during treatment

Note that paroxetine and fluoxetine should be avoided in women taking tamoxifen due to drug interactions Gabapentin : an anticonvulsant that may reduce vasomotor symptoms, particularly helpful for women with night sweats, though side effects include dizziness and fatigue Clonidine : an antihypertensive agent with modest efficacy for hot flashes, considered only when other options are unsuitable due to its side effect profile Cognitive behavioural therapy (CBT) : NICE-recommended psychological intervention that helps women manage the impact of symptoms Lifestyle modifications form an important foundation: Maintaining a healthy weight through balanced diet and regular physical activity Wearing layered clothing and keeping ambient temperature cool Avoiding known triggers (alcohol, caffeine, spicy foods) Practising stress-reduction techniques Ensuring good sleep hygiene When to contact your GP : Women should seek medical advice if hot flashes significantly impact quality of life, interfere with sleep or daily activities, or if symptoms occur alongside unexplained weight loss, night sweats with fever, or other concerning features

GLP-1 medications, such as Wegovy and Zepbound, are FDA-approved treatments designed to help patients lose weight by: Reducing appetite Slowing digestion Helping regulate blood sugar These medications are best suited for patients who want to lose overall body weight gradually over time

"I don't know how to present myself right now," she said at the time

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Oprah Winfrey During an interview with People in December 2023, Winfrey revealed that she takes a weight-loss drug, but didn't specify which one