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In SURPASS clinical trials, tirzepatide reduced the A1C by about 1.8 to 2.1% on average with 5 mg once weekly, while metformin reduced glycated hemoglobin levels by 1% to 1.5% after 3-6 months

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Tirzepatide should be administered subcutaneously in the abdomen, thigh, or upper arm, with site rotation to prevent lipohypertrophy or lipoatrophy that can impair absorption

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