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glp 1 receptor antagonists GLP-1 agonists show promise in treating substance use disorders The Impact of GLP-1 Receptor
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Metformin may help with modest weight loss, but its less effective than newer GLP1 agents in this regard

[DOI] [PubMed] [Google Scholar] 179.Elmehdawi RR, Elbarsha AM

Most prescription drugs require a BMI of 30 or higher, or 27 and above with weight-related health conditions like diabetes or high blood pressure
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doi: 10.1186/s12933-019-0966-2

However, further adequately powered studies are needed to directly compare this approach with medication withholding