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Exendin-4-stimulated GLP-1R triggers VAPB-localised cAMP generation and PKA activity at the outer mitochondrial membrane As stated above, besides VAPB, our interactome analysis highlighted several factors enriched for their association with active GLP-1R localised at the ER, mitochondria and/or ERMCSs, a location where VAPB plays a prominent organising role 17 , suggesting that ERMCSs could be a potential hub for endosomal GLP-1R signalling

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The Medicines and Healthcare products Regulatory Agency (MHRA) has approved Ozempic specifically for glycaemic control in type 2 diabetes, either as monotherapy when metformin is inappropriate or in combination with other glucose-lowering medications