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Lastly, a study evaluating the impact of IL-1 gene polymorphism, leading to increased IL-1 levels, was shown to correlate with an increased rate of kidney disease in T2DM, mainly diabetic nephropathy [8]
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Average weight gain from cessation to restarting the drug was 1.3%
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Less common but significant side effects observed in trials consist of altered skin sensation, severe dermal reactions, and increased susceptibility to allergic reactions
