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Further research is needed to more clearly elucidate both if GLP-1-mediated glucose uptake in hepatic tissue is exclusively through extrahepatic GLP-1R activation and if GLP-1R is distributed in human hepatic tissue

After a median follow-up of 2.3 years, GLP-1 RAs users exhibit reduced risks of mortality (adjusted hazard ratio [aHR]: 0.57), MACEs (aHR: 0.88), and MAKEs (aHR: 0.73)

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If you are working with a 10 mg vial, or planning to, this is the reference you will return to repeatedly

In this trial, the safety and tolerability of sitagliptin were generally similar to placebo
