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Important aspects to be considered are (1) their long half-lives, (2) the capacity of GLP-1 receptor agonism to slow gastric emptying even at physiological GLP-1 concentrations, (c) tachyphylaxis observed with prolonged treatment, and (d) the limited effect on gastric emptying in individuals with slow gastric emptying before initiating treatment

Effect on Metabolism and Fat Storage GLP-1s can improve insulin sensitivity, reduce inflammation, and encourage your body to burn more fat instead of storing it

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In clinical trials and other studies, those drugs outperform liraglutide, producing substantially more weight loss while causing fewer side effects

Fras JP, Auerbach P, Bajaj HS, Fukushima Y, LingvayI, Macura S, Sndergaard AL, Tankova TI, Tentolouris N, Buse JB