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Investigating differential responses based on patient demographics, genetic profiles, and specific pain conditions will also be crucial in developing personalized treatment strategies, thereby optimizing the therapeutic benefits of GLP-1R agonists for diverse patient populations

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For colorectal cancer, reductions in circulating insulin and systemic inflammation are plausible mechanisms, although further tissue-level validation is needed (Figure 5)

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doi: 10.2337/dc09-1203 55 Elkind-HirschKMarrioneauxOBhushanMVernorDBhushanR

Subsequent studies then confirmed the presence of GLP-1R in these and other insulinoma cell lines [[369], [370], [371], [372], [373], [374], [375], [376]] as well as in somatostatin-secreting cells [370,375] and in islets isolated from rats [377] and humans [378]
