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[2] The head-to-head ACHIEVE-3 trial, published in The Lancet in February 2026, compared orforglipron 36 mg to oral semaglutide 14 mg in 1,698 patients with type 2 diabetes over 52 weeks
Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction

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have obesity and another 30% have overweight
