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The most evidence-backed approach is testing for and correcting specific deficiencies
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The most commonly reported adverse events remain gastrointestinal by a wide margin, with constipation , headaches , and fatigue rounding out the list
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The subcutaneous layer may be less uniform, with areas of tissue thinning alternating with areas of normal thickness

Further advantages (see Box 2 ) have led the American Diabetes Association (ADA) to recommend incretin mimetics as the first-choice injectable glucose-lowering therapy for type 2 diabetes, ahead of insulin (ADA, 2026)
