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Despite the promising potential of GLP-1 RAs, it is essential to conduct further clinical studies to confirm their long-term efficacy and safety in patients with HFpEF

This bidirectional signaling pathway connecting the gastrointestinal tract and the central nervous system involves mechanisms associated with the intestinal peptides, in particular human incretin hormones such as anorexigenic GLP-1

Microdosing may actually help manage this process

2 (2016): 422437, 10.1111/adb.12295

Further, a reduced calorie intake is correlated with lower vitamin and mineral consumption [25]

Start at 0.6 mg SQ per day and increase by 0.6 mg per week as tolerated