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Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Summary: GLP-1 receptor agonists can modestly reduce systolic blood pressure by approximately 24 mmHg, though they are not licensed specifically as antihypertensive medications in the UK

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The most frequently reported side effects were mild to moderate nausea, diarrhea, and constipation

After overnight incubation, cells were transfected with GIPR, GLP-1R or GCGR construct using Lipofectamine 2000 transfection reagent (Invitrogen)

According to NICE guideline NG238, atorvastatin 20mg is recommended for primary prevention, with higher doses (atorvastatin 80mg or rosuvastatin 2040mg) for secondary prevention