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In a rat model of neurodegeneration, GLP-1 and exendin-4 ameliorated neurodegeneration by reducing ibotenic acid-induced depletion of cholinergic cell bodies, as demonstrated by preservation of choline acetyltransferase immunoreactivity in basal forebrain cholinergic neurons [826]

Results in one population may not translate directly to the other

Thirty to fifty grams per meal, distributed across three meals, covers most people's needs

released preliminary topline week 96 results from Phase 2b study HARMONY The study previously met its primary endpoint of 1 stage improvement in fibrosis with no worsening of MASH after 24 weeks of treatment for both the 50mg EFX (41%) and 28mg EFX (39%) dose groups, compared to 20% for the placebo arm

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