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Site-specific pegylated Exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects

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Fatigue affects roughly 13% of users during the first month, often related to reduced caloric intake as appetite suppression takes effect

Additionally, dissociated G subunits can also trigger signalling that leads to activation of both the calcium and the extracellular signal-regulated kinase (ERK1/2) pathways (Lymperopoulos et al., 2022)