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In clinical trials, serious adverse effects requiring discontinuation were reported in less than 2% (,,)
Cortisol promotes fat storage and muscle breakdown
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Ultrarapid insulins (ie, faster aspart, lispro aabc) have demonstrated earlier time of onset and action but similar duration of action
In the SYNERGY-NASH trial, tirzepatide achieved MASH (metabolic dysfunction-associated steatohepatitis) resolution without worsening fibrosis in up to 74% of patients at the highest dose, compared to 13% for placebo
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