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Pourhassan M, Bosy-Westphal A, Schautz B, Braun W, Gler CC, Mller MJ

Useful tracking points include: Baseline eye exam status Existing AMD diagnosis or family history Diabetes status and HbA1c trend Blood pressure and lipid markers Smoking history GLP-1 medication, dose, and start date Speed of weight loss New visual symptoms, distortion, blurred central vision, floaters, or dark spots Ophthalmology follow-up dates and findings PeptIQ is not a replacement for an eye exam

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Patients should be counseled to report severe abdominal pain immediately Gallbladder disease : Increased risk of cholelithiasis and cholecystitis, likely related to rapid weight loss Hypoglycemia : Risk is low when used alone but increases when combined with insulin or sulfonylureas Thyroid C-cell tumors : Based on rodent studies, these agents carry a boxed warning and are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Acute kidney injury : Can occur, particularly with dehydration from gastrointestinal side effects Diabetic retinopathy complications : Semaglutide may worsen diabetic retinopathy in patients with diabetes, particularly with rapid improvement in glucose control Severe gastrointestinal disease : Use with caution in patients with gastroparesis or severe gastrointestinal disease

In addition, it is difficult to apply the results of this study to humans because it is not common to administer GLP-1RA under fasting conditions in humans