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Shi Q, Nong K, Vandvik PO, Guyatt GH, Schnell O, Rydn L, et al

[1] [4] Tirzepatide is not indicated for patients with type 1 diabetes

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However, the proximity of APR is likely not the only driving criterion as the lipidation impact on solubility, structure, and bioactivity also play crucial roles

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GIP also induces osteopontin expression in adipocytes (65), an adipokine associated with obesity-related systemic low grade inflammation (66, 67)