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Triglycerides were significantly reduced at all doses of tirzepatide compared to placebo

Patients should be aware that GLP-1 medications are initiated and monitored within specialist or primary care diabetes services

However, it is important to note that these trials were primarily designed to assess glycaemic control endpoints, with median follow-up periods of 40104 weeksa timeframe that is insufficient to detect long-term cancer risks

Second, neurodegenerative indications highlight a similar gap between mechanistic promise and clinical outcomes

, which have surged in popularity due to their effectiveness in Previous studies have produced mixed results on whether these drugs are associated with eye complications, with some analyses finding a modest increase in NAION risk and others finding no elevated risk

Semaglutide may also influence reward pathways in the brain that govern food-seeking behavior and cravings, particularly for high-calorie, palatable foods