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4,6 A key issue in the physiology of type 2 diabetes (T2DM) is the reduced incretin effect, which mainly results from decreased activity of the primary incretin hormones, GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic peptide)

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Psychiatry 6 , e809 (2016)

JAMA 295(15):18241830 Chen S, Zhou M, Sun J, Guo A, Fernando RL, Chen Y, Peng P, Zhao G, Deng Y (2019) DPP-4 inhibitor improves learning and memory deficits and AD-like neurodegeneration by modulating the GLP-1 signaling

central nucleus of the amygdala, bed nucleus of the stria terminalis, organum vasculosum of the lamina terminalis (OVLT), anteroventral periventricular nucleus (AVPV) and median preoptic nucleus (MnPO)] and are predominately separate from calcitonin generelated peptide (CGRP) neurons in the parabrachial nucleus which decrease both food and fluid intake (Ryan et al., 2017) (the effects of GLP1 receptor signalling on feeding behaviour via actions in the parabrachial nucleus will be further discussed in section 3.4.1)